human igg4 constant region Search Results


igg4 control  (MedChemExpress)
94
MedChemExpress igg4 control
SM17 Abrogated Disease Phenotypes in HDM Extract-Induced Asthma Model. (A) Experiment timeline for HDM extract-induced model were shown. (B) H&E, PAS, toluidine blue, congo red and Masson’s trichrome staining were performed in paraffin-embedded lung sections. (C) SM17 significantly improved lung pathology as stimulated by HDM extract. (D–F) Goblet cells, mast cells and eosinophils in lung were all significantly reduced by SM17. (G) Masson’s trichome stains for collagen deposition and SM17 exhibited strong inhibitory effects on it, while dexamethasone did not. (H–J) Levels of IL-4, IL-5 and IL-13 in BALF were determined by ELISA. SM17 showed similar suppression as dexamethasone on all three Th2 cytokines. (K, L) Infiltration of ILC2 in BALF was analysed by flow cytometry as identified by the population Lineage CD45 + ICOS + ST2 + . Results indicated that SM17 possessed high suppressive effects on lung ILC2 numbers. Scale bar = 100μm. *P<.05; **P<.01 compared to <t>IgG4</t> control group by unpaired student t-test. #P<.05; ##P<0.01; ###P<0.005 as compared to saline control by unpaired student t-test. DEX, dexamethasone; HDM, house dust mite.
Igg4 Control, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+igg4+constant+region/Human+IgG4+Antibody/pmc11663749-106-13-22
Average 94 stars, based on 1 article reviews
igg4 control - by Bioz Stars, 2026-09
94/100 stars
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human igg4 antibody / hinge region  (NSJ Bioreagents)
99
NSJ Bioreagents human igg4 antibody / hinge region
SM17 Abrogated Disease Phenotypes in HDM Extract-Induced Asthma Model. (A) Experiment timeline for HDM extract-induced model were shown. (B) H&E, PAS, toluidine blue, congo red and Masson’s trichrome staining were performed in paraffin-embedded lung sections. (C) SM17 significantly improved lung pathology as stimulated by HDM extract. (D–F) Goblet cells, mast cells and eosinophils in lung were all significantly reduced by SM17. (G) Masson’s trichome stains for collagen deposition and SM17 exhibited strong inhibitory effects on it, while dexamethasone did not. (H–J) Levels of IL-4, IL-5 and IL-13 in BALF were determined by ELISA. SM17 showed similar suppression as dexamethasone on all three Th2 cytokines. (K, L) Infiltration of ILC2 in BALF was analysed by flow cytometry as identified by the population Lineage CD45 + ICOS + ST2 + . Results indicated that SM17 possessed high suppressive effects on lung ILC2 numbers. Scale bar = 100μm. *P<.05; **P<.01 compared to <t>IgG4</t> control group by unpaired student t-test. #P<.05; ##P<0.01; ###P<0.005 as compared to saline control by unpaired student t-test. DEX, dexamethasone; HDM, house dust mite.
Human Igg4 Antibody / Hinge Region, supplied by NSJ Bioreagents, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+igg4+constant+region/Human+IgG4+Antibody+%2F+Hinge+region/custom%40r20190btn%4010%2E1111%2F1467-9655%2E13344
Average 99 stars, based on 1 article reviews
human igg4 antibody / hinge region - by Bioz Stars, 2026-09
99/100 stars
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humanized anti–pd-1 abs igg4 fc region  (GenScript corporation)
90
GenScript corporation humanized anti–pd-1 abs igg4 fc region
SM17 Abrogated Disease Phenotypes in HDM Extract-Induced Asthma Model. (A) Experiment timeline for HDM extract-induced model were shown. (B) H&E, PAS, toluidine blue, congo red and Masson’s trichrome staining were performed in paraffin-embedded lung sections. (C) SM17 significantly improved lung pathology as stimulated by HDM extract. (D–F) Goblet cells, mast cells and eosinophils in lung were all significantly reduced by SM17. (G) Masson’s trichome stains for collagen deposition and SM17 exhibited strong inhibitory effects on it, while dexamethasone did not. (H–J) Levels of IL-4, IL-5 and IL-13 in BALF were determined by ELISA. SM17 showed similar suppression as dexamethasone on all three Th2 cytokines. (K, L) Infiltration of ILC2 in BALF was analysed by flow cytometry as identified by the population Lineage CD45 + ICOS + ST2 + . Results indicated that SM17 possessed high suppressive effects on lung ILC2 numbers. Scale bar = 100μm. *P<.05; **P<.01 compared to <t>IgG4</t> control group by unpaired student t-test. #P<.05; ##P<0.01; ###P<0.005 as compared to saline control by unpaired student t-test. DEX, dexamethasone; HDM, house dust mite.
Humanized Anti–Pd 1 Abs Igg4 Fc Region, supplied by GenScript corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+igg4+constant+region/humanized+anti+pd+1+abs+igg4+fc+region/pmc06605749-190-18-13
Average 90 stars, based on 1 article reviews
humanized anti–pd-1 abs igg4 fc region - by Bioz Stars, 2026-09
90/100 stars
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hcd64 protein  (MedChemExpress)
89
MedChemExpress hcd64 protein
SM17 Abrogated Disease Phenotypes in HDM Extract-Induced Asthma Model. (A) Experiment timeline for HDM extract-induced model were shown. (B) H&E, PAS, toluidine blue, congo red and Masson’s trichrome staining were performed in paraffin-embedded lung sections. (C) SM17 significantly improved lung pathology as stimulated by HDM extract. (D–F) Goblet cells, mast cells and eosinophils in lung were all significantly reduced by SM17. (G) Masson’s trichome stains for collagen deposition and SM17 exhibited strong inhibitory effects on it, while dexamethasone did not. (H–J) Levels of IL-4, IL-5 and IL-13 in BALF were determined by ELISA. SM17 showed similar suppression as dexamethasone on all three Th2 cytokines. (K, L) Infiltration of ILC2 in BALF was analysed by flow cytometry as identified by the population Lineage CD45 + ICOS + ST2 + . Results indicated that SM17 possessed high suppressive effects on lung ILC2 numbers. Scale bar = 100μm. *P<.05; **P<.01 compared to <t>IgG4</t> control group by unpaired student t-test. #P<.05; ##P<0.01; ###P<0.005 as compared to saline control by unpaired student t-test. DEX, dexamethasone; HDM, house dust mite.
Hcd64 Protein, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 89/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+igg4+constant+region/CD64%2C+Human/pm41543848-78-12-15
Average 89 stars, based on 1 article reviews
hcd64 protein - by Bioz Stars, 2026-09
89/100 stars
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Image Search Results


SM17 Abrogated Disease Phenotypes in HDM Extract-Induced Asthma Model. (A) Experiment timeline for HDM extract-induced model were shown. (B) H&E, PAS, toluidine blue, congo red and Masson’s trichrome staining were performed in paraffin-embedded lung sections. (C) SM17 significantly improved lung pathology as stimulated by HDM extract. (D–F) Goblet cells, mast cells and eosinophils in lung were all significantly reduced by SM17. (G) Masson’s trichome stains for collagen deposition and SM17 exhibited strong inhibitory effects on it, while dexamethasone did not. (H–J) Levels of IL-4, IL-5 and IL-13 in BALF were determined by ELISA. SM17 showed similar suppression as dexamethasone on all three Th2 cytokines. (K, L) Infiltration of ILC2 in BALF was analysed by flow cytometry as identified by the population Lineage CD45 + ICOS + ST2 + . Results indicated that SM17 possessed high suppressive effects on lung ILC2 numbers. Scale bar = 100μm. *P<.05; **P<.01 compared to IgG4 control group by unpaired student t-test. #P<.05; ##P<0.01; ###P<0.005 as compared to saline control by unpaired student t-test. DEX, dexamethasone; HDM, house dust mite.

Journal: Frontiers in Immunology

Article Title: Evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of SM17 in healthy volunteers: results from pre-clinical models and a first-in-human, randomized, double blinded clinical trial

doi: 10.3389/fimmu.2024.1495540

Figure Lengend Snippet: SM17 Abrogated Disease Phenotypes in HDM Extract-Induced Asthma Model. (A) Experiment timeline for HDM extract-induced model were shown. (B) H&E, PAS, toluidine blue, congo red and Masson’s trichrome staining were performed in paraffin-embedded lung sections. (C) SM17 significantly improved lung pathology as stimulated by HDM extract. (D–F) Goblet cells, mast cells and eosinophils in lung were all significantly reduced by SM17. (G) Masson’s trichome stains for collagen deposition and SM17 exhibited strong inhibitory effects on it, while dexamethasone did not. (H–J) Levels of IL-4, IL-5 and IL-13 in BALF were determined by ELISA. SM17 showed similar suppression as dexamethasone on all three Th2 cytokines. (K, L) Infiltration of ILC2 in BALF was analysed by flow cytometry as identified by the population Lineage CD45 + ICOS + ST2 + . Results indicated that SM17 possessed high suppressive effects on lung ILC2 numbers. Scale bar = 100μm. *P<.05; **P<.01 compared to IgG4 control group by unpaired student t-test. #P<.05; ##P<0.01; ###P<0.005 as compared to saline control by unpaired student t-test. DEX, dexamethasone; HDM, house dust mite.

Article Snippet: The pre-clinical antibody formulation of SM17 (either 5 or 2.5 mg/kg), saline control, IgG4 control (5 mg/kg) and dexamethasone (DEX, 1 mg/kg; MCE, Monmouth Junction, NJ) were injected intraperitoneally to designated treatment groups on Day 1, 8, 10 and 12.

Techniques: Staining, Enzyme-linked Immunosorbent Assay, Flow Cytometry, Control, Saline